my mate had a panic attack and called an ambulance yesterday

i’m not certain what he did yet but i’ve heard mephedrone and shit mdma

tbh the boy had this comin the shit he does to himself on a daily basis

@DJCliffy 349405 wrote:

Everything in moderation folks.

including moderation? it kinda cancels itself out :laugh_at:

@p0ly 349406 wrote:

including moderation? it kinda cancels itself out :laugh_at:

Hmmm i might have phrased that incorrectly :weee:

@globalloon 349355 wrote:

i’ve tried lone and drone and thought it was like a 5 hour speed hit with a sicky feeling in my stomach

snorting = no stomach discomfort

probaly a good thing, don’t ever take it again

@joshmow56 349451 wrote:

Yeah, some people are blaming the actual recession for the lack of mandy.

If I had mandy, I’d know when i’d had enough and i’d be able to get a bloody nights sleep after.

It’s still out there but it’s very hard to find. I have heard of ppl buying old school crystal mud at £50 a g.

Then again i’d probably pay that for a bit of decent mandy! 😉

I got this from a post on drugs-forum.. (DA is dopamine).

Note the warnings about the effects on the heart…

4-methylmethcathinone

Legal: Under Australian law, in most states 4-Methylmethcathinone can be considered an analogue of the scheduled (illicit) drug methcathinone.

Pharmacological: 4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1)

Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2)

Quote:
Compared with controls, abstinent methamphetamine
and methcathinone users had significant decreases in
DAT density in the caudate nucleus (223 and 224%, respectively)
and putamen (225 and 216%, respectively).

It can be speculated that the para substituted compound 4-methylmethcathinone may have reduced stimulant activity, but as said, its likely to have additional affect on serotonin via both monoamine reuptake/ SERT inhibition and direct agonist affects of the 5HT2b receptors. Concerns have been raised regarding the actions of 4-methylmethcathinone in relation to peripheral 5HT (serotonin) stimulation and how that, combined with other catecholamine activity, may be dangerous to the heart.

In a similar manner to which pulmonary hypertension is caused by peripheral 5HT produced by gastrointestinal carcinoid tumours (and some argue 5HTP), other 5HT2b agonists have been found to cause this effect, which would be exacerbated by increased DA/NE levels and their corresponding affect on the heart. Longer term, such stimulation has been shown to result in fibroblast mitosis of the mitral valve of the left atrium (specifically the Chordae Tendineae). (3,4)

While it has yet to be demonstrated by means of scientific study that 4-methylmethcathinone produces these effects, I believe it’s wise to consider carefully the possible toxicity of this compound if you’re intending to ingest or otherwise consume products containing this drug.

Analysis of Neorganics Products: 5 new drugs banned in Israel – Drugs Forum

@p0ly 349423 wrote:

cliffy wanks in moderation? the pope must piss in the woods then

I need to calm down on that front. starting to go blind in one eye.

@General Lighting 349481 wrote:

aim more carefully then :laugh_at:

Might need to invest in a decent defence strategy ie a sock. :weee:

@joshd96320 349485 wrote:

:laugh_at::laugh_at::laugh_at:

wank socks, classic

wouldnt they go crusty after a while? :laugh_at::laugh_at::laugh_at::laugh_at::laugh_at::laugh_at:

how about a mask

The beauty of a wank sock is that upon crustation they can simply be thrown out and a new wank sock employed.

@Funnisam 349494 wrote:

wow… thanks for the very useful info lightning.

Don’t think i’ll be taking much more of this then o.o

I would read the warnings in context. A certain amount of the text is speculation and a comparison with cathinone itself (which isn’t sold on line as its a classified drug here). but people are reporting “heart/breathing” type problems on heavy doses

It is easy to get frightened by all the heavy medical words, but the toxicity of 4-MMC seems equivalent to that of dexamfetamine which has been used both recreationally and by the “legit” medical profession for decades.

bear in mind that recreational dexamfetamine and MDMA users are not always getting pure stuff whilst mephedrone is usually much purer – hence people taking larger doses by accident.

That document has been around for a long time. I was a bit concerned on reading it but my dr listened to my heart and said its fine/valves are fine. Also I repeat if u are worried about ur heart then go to the dr’s and get it checked it takes 2 mins for a dr to listen to ur heart with a stethescope and tell u if theres anything wrong with ur heart valves.

If u are getting a sore chest while doing mephedrone its quite simple. dont do any more mephedrone regardless of if its done serious damage or not.

But its also worth pointing out people who appear to be getting any trouble from it are binge takers. i plead guilty to that
put cocaine at 10 quid a gram and make it legal and the same problems would occur